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Target
Substance-P receptor
Ligand
BDBM50284879
Substrate
n/a
Meas. Tech.
ChEBML_141773
IC50
38±n/a nM
Citation
 Grisonl, S; Huon, C; Peyronel, JF 4,4-Diphenyl-7-perhydrothiapyrano[3,4-c]pyrrolone, a new series of substance P receptors antagonists Bioorg Med Chem Lett 5:1591-1594 (1995)    Article 
Target
Name:
Substance-P receptor
Synonyms:
NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46254.43
Organism:
Homo sapiens (Human)
Description:
P25103
Residue:
407
Sequence:
MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
  
Inhibitor
Name:
BDBM50284879
Synonyms:
1-[7-Hydroxy-7-(2-methoxy-phenyl)-4,4-diphenyl-hexahydro-thiopyrano[3,4-c]pyrrol-2-yl]-2-(2-methoxy-phenyl)-propan-1-one | CHEMBL295845
Type:
Small organic molecule
Emp. Form.:
C36H37NO4S
Mol. Mass.:
579.748
SMILES:
COc1ccccc1[C@H](C)C(=O)N1C[C@H]2[C@@H](C1)C(SC[C@]2(O)c1ccccc1OC)(c1ccccc1)c1ccccc1
Structure:
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