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Target
Substance-P receptor
Ligand
BDBM50284883
Substrate
n/a
Meas. Tech.
ChEBML_141782
IC50
77±n/a nM
Citation
 Grisonl, S; Huon, C; Peyronel, JF 4,4-Diphenyl-7-perhydrothiapyrano[3,4-c]pyrrolone, a new series of substance P receptors antagonists Bioorg Med Chem Lett 5:1591-1594 (1995)    Article 
Target
Name:
Substance-P receptor
Synonyms:
NK-1 receptor | NK-1R | NK1 Receptor | NK1R_RAT | Neurokinin 1 receptor | Neurokinin NK1 | SPR | Substance-P receptor | Tac1r | Tachykinin receptor 1 | Tacr1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46371.54
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected CHO cells that constitutively expressed the rat NK1 receptor.
Residue:
407
Sequence:
MDNVLPMDSDLFPNISTNTSESNQFVQPTWQIVLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHVFFLLPYINPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQSSVYKVSRLETTISTVVGAHEEEPEEGPKATPSSLDLTSNGSSRSNSKTMTESSSFYSNMLA
  
Inhibitor
Name:
BDBM50284883
Synonyms:
2-(2-Dimethylamino-phenyl)-1-(7-hydroxy-4,4-diphenyl-hexahydro-thiopyrano[3,4-c]pyrrol-2-yl)-ethanone | CHEMBL41375
Type:
Small organic molecule
Emp. Form.:
C29H32N2O2S
Mol. Mass.:
472.642
SMILES:
CN(C)c1ccccc1CC(=O)N1C[C@H]2[C@@H](C1)C(SC[C@@H]2O)(c1ccccc1)c1ccccc1
Structure:
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