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Target
Cysteinyl leukotriene receptor 1
Ligand
BDBM50284899
Substrate
n/a
Meas. Tech.
ChEMBL_98639 (CHEMBL711839)
IC50
0.700±n/a nM
Citation
 Lau, CK; Dufresne, C; Gareau, Y; Zamboni, R; Labelle, M; Young, RN; Metters, KM; Rochette, C; Sawyer, N; Slipetz, DM; Charette, L; Jones, T; McAuliffe, M; McFarlane, C; Ford-Hutchinson, AW Evolution of a series of non-quinoline leukotriene D4 receptor antagonist; synthesis and sar of benzothiazoles and thiazoles substituted benzyl alcohols as potent LTD4 antagonists Bioorg Med Chem Lett 5:1615-1620 (1995)    Article 
Target
Name:
Cysteinyl leukotriene receptor 1
Synonyms:
CLTR1_CAVPO | CYSLTR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39007.58
Organism:
GUINEA PIG
Description:
Leukotriene D4 0 GUINEA PIG::Q2NNR5
Residue:
340
Sequence:
MDETGNPTIPPASNNTCYDSIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLVKTYHEKSAFQVYMINLAVADLLCVCTLPLRVAYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCVAIVFPVQNISLVTQKKARLVCIAIWMFVILTSSPFLMANTYKDEKNNTKCFEPPQDNQAKNYVLILHYVSLFIGFIIPFITIIVCYTMIIFTLLKSSMKKNLSSRKRAIGMIIVVTAAFLVSFMPYHIQRTIHLHFLHNKTKPCDSILRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRRRLSTIRKYSLSSMTYIPKKKTSLPQKGKDICKE
  
Inhibitor
Name:
BDBM50284899
Synonyms:
CHEMBL287722 | {1-[(R)-3-[2-(1-Hydroxy-1-methyl-ethyl)-phenyl]-1-(3-{(E)-2-[4-(3,3,3-trifluoro-1-methyl-propyl)-thiazol-2-yl]-vinyl}-phenyl)-propylsulfanylmethyl]-cyclopropyl}-acetic acid
Type:
Small organic molecule
Emp. Form.:
C33H38F3NO3S2
Mol. Mass.:
617.785
SMILES:
CC(CC(F)(F)F)c1csc(\C=C\c2cccc(c2)[C@@H](CCc2ccccc2C(C)(C)O)SCC2(CC(O)=O)CC2)n1
Structure:
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