Reaction Details Report a problem with these data
Target
Platelet-activating factor receptor
Ligand
BDBM50286005
Substrate
n/a
Meas. Tech.
ChEBML_155158
Ki
180±n/a nM
Citation
 Holms, JH; Davidsen, SK; Sheppard, GS; Carrera, GM; Curtin, NL; Heyman, HR; Pireh, D; Steinman, DH; Albert, DH; Conway, RG; Luo, G; Magoc, TJ; Tapang, P; Rhein, DA; Summers, JB Discovery and optimization of indole pyrrolothiazole paf antagonists Bioorg Med Chem Lett 5:2903-2908 (1995)    Article 
Target
Name:
Platelet-activating factor receptor
Synonyms:
PAF-R | PTAFR | PTAFR_CAVPO | Platelet activating factor receptor | Platelet-activating factor receptor
Type:
Protein
Mol. Mass.:
39005.63
Organism:
Cavia porcellus
Description:
n/a
Residue:
342
Sequence:
MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
  
Inhibitor
Name:
BDBM50286005
Synonyms:
(5-Benzyloxy-1H-indol-3-yl)-(3-pyridin-3-yl-1H-pyrrolo[1,2-c]thiazol-7-yl)-methanone | CHEMBL329508
Type:
Small organic molecule
Emp. Form.:
C27H21N3O2S
Mol. Mass.:
451.54
SMILES:
O=C(c1ccn2C(SCc12)c1cccnc1)c1c[nH]c2ccc(OCc3ccccc3)cc12
Structure:
Search PDB for entries with ligand similarity: