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Target
Squalene monooxygenase
Ligand
BDBM50286538
Substrate
n/a
Meas. Tech.
ChEMBL_201937 (CHEMBL809124)
pH
8.8±n/a
IC50
32000±n/a nM
Comments
extracted
Citation
 Denner-Ancona, P; Bai, M; Lee, HK; Abe, I; Prestwich, GD Purification of pig and rat liver squalene epoxidase by affinity chromatography Bioorg Med Chem Lett 5:481-486 (1995)    Article 
Target
Name:
Squalene monooxygenase
Synonyms:
ERG1 | ERG1_HUMAN | SE | SQLE | Squalene epoxidase
Type:
PROTEIN
Mol. Mass.:
63936.94
Organism:
Homo sapiens (Human)
Description:
ChEMBL_201924
Residue:
574
Sequence:
MWTFLGIATFTYFYKKFGDFITLANREVLLCVLVFLSLGLVLSYRCRHRNGGLLGRQQSGSQFALFSDILSGLPFIGFFWAKSPPESENKEQLEARRRRKGTNISETSLIGTAACTSTSSQNDPEVIIVGAGVLGSALAAVLSRDGRKVTVIERDLKEPDRIVGEFLQPGGYHVLKDLGLGDTVEGLDAQVVNGYMIHDQESKSEVQIPYPLSENNQVQSGRAFHHGRFIMSLRKAAMAEPNAKFIEGVVLQLLEEDDVVMGVQYKDKETGDIKELHAPLTVVADGLFSKFRKSLVSNKVSVSSHFVGFLMKNAPQFKANHAELILANPSPVLIYQISSSETRVLVDIRGEMPRNLREYMVEKIYPQIPDHLKEPFLEATDNSHLRSMPASFLPPSSVKKRGVLLLGDAYNMRHPLTGGGMTVAFKDIKLWRKLLKGIPDLYDDAAIFEAKKSFYWARKTSHSFVVNILAQALYELFSATDDSLHQLRKACFLYFKLGGECVAGPVGLLSVLSPNPLVLIGHFFAVAIYAVYFCFKSEPWITKPRALLSSGAVLYKACSVIFPLIYSEMKYMVH
  
Inhibitor
Name:
BDBM50286538
Synonyms:
6,11,15,19-tetramethyl-2-(4-methyl-3-pentenyl)-(2Z,6E,10E,14E)-2,6,10,14,18-icosapentaen-1-amine | CHEMBL358117
Type:
Small organic molecule
Emp. Form.:
C30H51N
Mol. Mass.:
425.7326
SMILES:
[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]-[#6]=[#6](-[#6])-[#6]-[#6]\[#6]=[#6](/[#6]-[#7])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]
Structure:
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