Reaction Details Report a problem with these data
Target
Retinoic acid receptor gamma
Ligand
BDBM50097824
Substrate
n/a
Meas. Tech.
ChEMBL_196170 (CHEMBL804943)
EC50
10±n/a nM
Citation
 Chandraratna, RA; Gillett, SJ; Song, TK; Attard, J; Vuligonda, S; Garst, ME; Arefieg, T; Gil, DW; Wheeler, L Synthesis and pharmacological activity of conformationally restricted, acetylenic retinoid analogs Bioorg Med Chem Lett 5:523-527 (1995)    Article 
Target
Name:
Retinoic acid receptor gamma
Synonyms:
NR1B3 | Nuclear receptor subfamily 1 group B member 3 | RAR-gamma | RARG | RARG_HUMAN | Retinoic acid receptor RXR-alpha/gamma | Retinoic acid receptor gamma | Retinoid receptor
Type:
PROTEIN
Mol. Mass.:
50345.43
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1458016
Residue:
454
Sequence:
MATNKERLFAAGALGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMASLSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEMFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSPA
  
Inhibitor
Name:
BDBM50097824
Synonyms:
4-[(E)-4-(2,6,6-Trimethyl-cyclohex-1-enyl)-but-3-en-1-ynyl]-benzoic acid | CHEMBL151870
Type:
Small organic molecule
Emp. Form.:
C20H22O2
Mol. Mass.:
294.3875
SMILES:
CC1=C(\C=C\C#Cc2ccc(cc2)C(O)=O)C(C)(C)CCC1 |c:1|
Structure:
Search PDB for entries with ligand similarity: