Reaction Details Report a problem with these data
Target
Platelet-activating factor receptor
Ligand
BDBM50286667
Substrate
n/a
Meas. Tech.
ChEBML_151697
IC50
26.0±n/a nM
Citation
 Hussoin, MS; Cai, X; Scannell, RT; Yaeger, D; Killian, DB; Eckman, J; Hwang, SB; Libertine-Garahan, L; Qian, C; Yen, CG; Ip, S Cmi-206: A potent dual platelet activating factor antagonist and 5-lipoxygenase inhibitor Bioorg Med Chem Lett 5:643-648 (1995)    Article 
Target
Name:
Platelet-activating factor receptor
Synonyms:
PAF Platelet activating factor | PAF-R | PAFR | PTAFR | PTAFR_HUMAN | Platelet activating factor receptor | Platelet-activating factor receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39219.60
Organism:
Homo sapiens (Human)
Description:
PAF Platelet activating factor PTAFR HUMAN::P25105
Residue:
342
Sequence:
MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLTMADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVTRPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKGSVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN
  
Inhibitor
Name:
BDBM50286667
Synonyms:
CHEMBL155851 | N-hydroxy-N'-[3-methoxy-5-(5-(3,4,5-trimethoxyphenyl)tetrathydrofuran-2-yl)-2-propoxyphenyl]-N-(tert-butyl)-N-hydroxyurea
Type:
Small organic molecule
Emp. Form.:
C28H40N2O8
Mol. Mass.:
532.6258
SMILES:
CCCOc1c(NC(=O)N(O)C(C)(C)C)cc(cc1OC)C1CCC(O1)c1cc(OC)c(OC)c(OC)c1
Structure:
Search PDB for entries with ligand similarity: