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Target
Substance-K receptor
Ligand
BDBM50287397
Substrate
n/a
Meas. Tech.
ChEBML_143050
IC50
2790±n/a nM
Citation
 Ofner, S; Hauser, K; Schilling, W; Vassout, A; Veenstra, SJ SAR of 2-benzyl-4-aminopiperidines: CGP 49823, an orally and centrally active non-peptide NK1 antagonist Bioorg Med Chem Lett 6:1623-1628 (1996)    Article 
Target
Name:
Substance-K receptor
Synonyms:
NK-2 receptor | NK-2R | NK2R_BOVIN | Neurokinin 2 receptor | Neurokinin A receptor | SKR | Substance-K receptor | TAC2R | TACR2 | Tachykinin receptor 2
Type:
PROTEIN
Mol. Mass.:
43078.78
Organism:
Bos taurus
Description:
ChEMBL_143050
Residue:
384
Sequence:
MGACVVMTDINISSGLDSNATGITAFSMPGWQLALWTAAYLALVLVAVMGNATVIWIILAHQRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPGTRAVIAGIWLVALALAFPQCFYSTITTDEGATKCVVAWPEDSGGKMLLLYHLIVIALIYFLPLVVMFVAYSVIGLTLWRRSVPGHQAHGANLRHLQAKKKFVKTMVLVVVTFAICWLPYHLYFILGTFQEDIYCHKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTEEDKMELTYTPSLSTRVNRCHTKEIFFMSGDVAPSEAVNGQAESPQAGVSTEP
  
Inhibitor
Name:
BDBM50287397
Synonyms:
CGP-49823 | CHEMBL290364 | {(2R,4S)-2-Benzyl-4-[(quinolin-4-ylmethyl)-amino]-piperidin-1-yl}-(3,5-dimethyl-phenyl)-methanone | {(R)-2-Benzyl-4-[(quinolin-4-ylmethyl)-amino]-piperidin-1-yl}-(3,5-dimethyl-phenyl)-methanone
Type:
Small organic molecule
Emp. Form.:
C31H33N3O
Mol. Mass.:
463.6132
SMILES:
Cc1cc(C)cc(c1)C(=O)N1CC[C@@H](C[C@H]1Cc1ccccc1)NCc1ccnc2ccccc12
Structure:
Search PDB for entries with ligand similarity: