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Target
Substance-P receptor
Ligand
BDBM50288567
Substrate
n/a
Meas. Tech.
ChEBML_144909
IC50
27±n/a nM
Citation
 Veenstra, SJ; Hauser, K; Schilling, W; Betschart, C; Ofner, S SAR of 2-benzyl-4-aminopiperidines NK1 antagonists. Part 21. synthesis of CGP 49823 Bioorg Med Chem Lett 6:3029-3034 (1996)    Article 
Target
Name:
Substance-P receptor
Synonyms:
NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46254.43
Organism:
Homo sapiens (Human)
Description:
P25103
Residue:
407
Sequence:
MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
  
Inhibitor
Name:
BDBM50288567
Synonyms:
(3,5-Dimethyl-phenyl)-{(2R,4S)-2-(3-methoxy-benzyl)-4-[(quinolin-4-ylmethyl)-amino]-piperidin-1-yl}-methanone | CHEMBL321710
Type:
Small organic molecule
Emp. Form.:
C32H35N3O2
Mol. Mass.:
493.6392
SMILES:
COc1cccc(C[C@@H]2C[C@H](CCN2C(=O)c2cc(C)cc(C)c2)NCc2ccnc3ccccc23)c1
Structure:
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