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Target
Glutathionylspermidine synthase
Ligand
BDBM50288579
Substrate
n/a
Meas. Tech.
ChEBML_219279
Ki
290000±n/a nM
Citation
 Verbruggen, C; Craecker, SD; Rajan, P; Jiao, XY; Borloo, M; Smith, K; Fairlamb, AH; Haemers, A Phosphonic acid and phosphinic acid tripeptides as inhibitors of glutathionylspermidine synthetase Bioorg Med Chem Lett 6:253-258 (1996)    Article 
Target
Name:
Glutathionylspermidine synthase
Synonyms:
GSP | GSP_CRIFA
Type:
PROTEIN
Mol. Mass.:
80299.94
Organism:
Crithidia fasciculata
Description:
ChEMBL_72759
Residue:
719
Sequence:
MSSLPHNHHYETHHRGTAEVPFDELIGVTPDGVPVISNGNEAHFSNLESITAACLPLSSFERKAPCKQPYRKMGVKWQCVEFVRRYLASRKAVWMTSLCTAEEVWREENLFVDVRDGRPVEVVRTPNKSTGPAPAVADIVVWGEGPETPFGHVAIVTEVCASCVRVAEQNQGFEKWPEDVPFSREIAMRTTESGEVELLDEDPLLGWVTVQAPFYNFDDGDLADSFRLVVGQGQILRQPFPKHVDVPWLNTGEECDTILKHSLVVDGNMGEGAHAEEGDVPGAFYFLDYDMFCRLGRAASSLHRIAMAATAKVLEDPESTHLLEHYFGVPPEIQPLLRRSWEMTPPMGGRFDFGYDGKNVVMLEYNCDSSGALLECCNTQEKMARFYGVSQGTSTGSFLGAKCVTYFQRLLTNEKVCPQHRLIHFMIDEDDEERYTARCMMGFAEQAGFRTKLCVKLVNFRYRDGPPSNAAPLATPCDHPTIVDGEDEEVLMVWKTWSWDTVLHQYHSQRSSSDAVNTPTLSDILLNNNIRVLEPLWKAVTGSKAILPFMHALAPDHEHMLAASFLPTREIISRHYISKPVNGRAGQNIMMYDPVTSPTELEGAPQQDICEALSQNASARSLLNGSPLPLSQSVDQTNECSPGKFFDSVLVYQQRLFLKKFDGKYFPIFCGWMVGDEFGGVVVREDTSKITKLSSMVVPARVVRDNVPLGVSYSDEGET
  
Inhibitor
Name:
BDBM50288579
Synonyms:
(S)-4-Amino-4-[(S)-2-methyl-1-(phosphonomethyl-carbamoyl)-propylcarbamoyl]-butyric acid | CHEMBL86137
Type:
Small organic molecule
Emp. Form.:
C11H22N3O7P
Mol. Mass.:
339.282
SMILES:
CC(C)[C@H](NC(=O)[C@@H](N)CCC(O)=O)C(=O)NCP(O)(O)=O
Structure:
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