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Target
Peptidyl-prolyl cis-trans isomerase FKBP1A
Ligand
BDBM50288762
Substrate
n/a
Meas. Tech.
ChEBML_195891
Ki
280±n/a nM
Citation
 Babine, RE; Bleckman, TM; Littlefield, ES; Parge, HE; Pelletier, LA; Lewis, CT; French, JV; Imbacuan, M; Katoh, S; Tatlock, JH; Showalter, RE; Villafranca, JE Design, synthesis and X-ray crystallographic studies of [7.3.1] and [8.3.1] macrocyclic FKBP-12 ligands Bioorg Med Chem Lett 6:385-390 (1996)    Article 
Target
Name:
Peptidyl-prolyl cis-trans isomerase FKBP1A
Synonyms:
12 kDa FK506-binding protein | 12 kDa FKBP | FK506-binding protein 1A | FK506-binding protein 1A (FKBP12) | FKB1A_HUMAN | FKBP-12 | FKBP-1A | FKBP1 | FKBP12 | FKBP1A | Immunophilin FKBP12 | PPIase | PPIase FKBP1A | Peptidyl-prolyl cis-trans isomerase (FKBP) | Rotamase | RyR1/FKBP12 | mTOR/FKBP12A/FKBP12B
Type:
Isomerase
Mol. Mass.:
11953.09
Organism:
Homo sapiens (Human)
Description:
P62942
Residue:
108
Sequence:
MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
  
Inhibitor
Name:
BDBM50288762
Synonyms:
(1S,10R)-14-[2-Oxo-2-(3,4,5-trimethoxy-phenyl)-acetyl]-3,8-dioxa-14-aza-bicyclo[8.3.1]tetradecane-2,9-dione | CHEMBL126473
Type:
Small organic molecule
Emp. Form.:
C22H27NO9
Mol. Mass.:
449.4511
SMILES:
COc1cc(cc(OC)c1OC)C(=O)C(=O)N1[C@@H]2CCC[C@H]1C(=O)OCCCCOC2=O
Structure:
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