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Target
Stromelysin-1
Ligand
BDBM50290087
Substrate
n/a
Meas. Tech.
ChEBML_205639
IC50
2175±n/a nM
Citation
 Broadhurst, MJ; Brown, PA; Lawton, G; Ballantyne, N; Borkakoti, N; Bottomley, KM; Cooper, MI; Eatherton, AJ; Kilford, IR; Malsher, PJ; Nixon, JS; Lewis, EJ; Sutton, BM; Johnson, WH Design and synthesis of the cartilage protective agent (CPA, Ro32-3555) Bioorg Med Chem Lett 7:2299-2302 (1997)    Article 
Target
Name:
Stromelysin-1
Synonyms:
MMP-3 | MMP3 | MMP3_HUMAN | Matrix metalloproteinase (2 and 3) | Matrix metalloproteinase 3 | Matrix metalloproteinase-3 | Matrix metalloproteinase-3 (MMP-3) | Matrix metalloproteinase-3 (MMP3) | SL-1 | STMY1 | Stromelysin 1 | Transin-1
Type:
Enzyme
Mol. Mass.:
53973.13
Organism:
Homo sapiens (Human)
Description:
P08254
Residue:
477
Sequence:
MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPVVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVSTLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
  
Inhibitor
Name:
BDBM50290087
Synonyms:
(2S,3R)-5-Methyl-3-(piperidine-1-carbonyl)-2-(3,4,4-trimethyl-2,5-dioxo-imidazolidin-1-ylmethyl)-hexanoic acid hydroxyamide | CHEMBL305729
Type:
Small organic molecule
Emp. Form.:
C20H34N4O5
Mol. Mass.:
410.5078
SMILES:
CC(C)C[C@H]([C@@H](CN1C(=O)N(C)C(C)(C)C1=O)C(=O)NO)C(=O)N1CCCCC1
Structure:
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