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Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50290758
Substrate
n/a
Meas. Tech.
ChEBML_1238
IC50
150±n/a nM
Citation
 Mátyus, P; Varga, I; Zára, E; Mezei, A; Behr, &; Simay, A; Haider, N; Boros, S; Bakonyi, A; Horváth, E; Horváth, K Novel pyridazino[4,5-b][1,5]oxazepines and -thiazepines as 5-HT1A receptor ligands Bioorg Med Chem Lett 7:2857-2862 (1997)    Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46445.29
Organism:
Rattus norvegicus (rat)
Description:
Binding assays were performed using rat hippocampal membranes.
Residue:
422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
  
Inhibitor
Name:
BDBM50290758
Synonyms:
3-Methyl-9-[3-(2-phenoxy-ethylamino)-propionyl]-6,7,8,9-tetrahydro-3H-5-thia-2,3,9-triaza-benzocyclohepten-4-one | CHEMBL318926
Type:
Small organic molecule
Emp. Form.:
C19H24N4O3S
Mol. Mass.:
388.484
SMILES:
Cn1ncc2N(CCCSc2c1=O)C(=O)CCNCCOc1ccccc1
Structure:
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