Reaction Details Report a problem with these data
Target
Gag-Pol polyprotein [489-587]
Ligand
BDBM1088
Substrate
n/a
Meas. Tech.
ChEBML_157705
Ki
15±n/a nM
Citation
 De Lucca, GV Synthesis and evaluation of delta lactams as nonpeptide HIV-protease inhibitors Bioorg Med Chem Lett 7:501-504 (1997)    Article 
Target
Name:
Gag-Pol polyprotein [489-587]
Synonyms:
Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10781.16
Organism:
Human immunodeficiency virus type 1
Description:
P04585[489-587]
Residue:
99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
  
Inhibitor
Name:
BDBM1088
Synonyms:
(4R,5R,6R)-1,3,4-tribenzyl-5-hydroxy-6-(2-phenylethyl)-1,3-diazinan-2-one | (4R,5R,6R)-Tetrahydro-1,3,6-tris(phenylmethyl)-5-hydroxy-4-(2-phenylethyl)-2(1H)-pyrimidinone | Tetrahydropyrimidinone deriv. 19
Type:
Small organic molecule
Emp. Form.:
C33H34N2O2
Mol. Mass.:
490.6353
SMILES:
O[C@@H]1[C@@H](CCc2ccccc2)N(Cc2ccccc2)C(=O)N(Cc2ccccc2)[C@@H]1Cc1ccccc1 |r|
Structure:
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