Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM50292213
Substrate
n/a
Meas. Tech.
ChEMBL_303010 (CHEMBL830249)
Ki
>10000±n/a nM
Citation
 Wei, J; Shao, X; Gong, M; Zhu, B; Cui, Y; Gao, Y; Wang, R. Structure-activity relationships of novel endomorphin-2 analogues with N-O turns induced by alpha-aminoxy acids. Bioorg Med Chem Lett 15:2986-2989 (2005) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44503.11
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor.
Residue:
398
Sequence:
MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50292213
Synonyms:
2-((S)-2-{2-[1-Amino-2-((R)-4-hydroxy-phenyl)-ethoxyamino]-acetylamino}-3-phenyl-propionylamino)-3-(S)-phenyl-propionamide | CHEMBL197569
Type:
Small organic molecule
Emp. Form.:
C28H33N5O5
Mol. Mass.:
519.5921
SMILES:
N[C@@H](Cc1ccc(O)cc1)ONCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Structure:
Search PDB for entries with ligand similarity: