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Target
Endothelin-1 receptor
Ligand
BDBM50292475
Substrate
n/a
Meas. Tech.
ChEMBL_507944 (CHEMBL937907)
IC50
40000±n/a nM
Citation
 Hussain, RA; Dickey, JK; Rosser, MP; Matson, JA; Kozlowski, MR; Brittain, RJ; Webb, ML; Rose, PM; Fernandes, P A Novel Class of Non-Peptidic Endothelin Antagonists Isolated from the Medicinal Herb Phyllanthus niruri J Nat Prod 58:1515-1520 (1995)    Article 
Target
Name:
Endothelin-1 receptor
Synonyms:
EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48736.88
Organism:
Homo sapiens (Human)
Description:
P25101
Residue:
427
Sequence:
METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRSSHKDSMN
  
Inhibitor
Name:
BDBM50292475
Synonyms:
CHEMBL510130 | hypophyllanthin
Type:
Small organic molecule
Emp. Form.:
C24H30O7
Mol. Mass.:
430.4908
SMILES:
COC[C@@H]1Cc2cc(OC)c3OCOc3c2[C@@H]([C@H]1COC)c1ccc(OC)c(OC)c1 |r|
Structure:
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