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Target
Luciferin 4-monooxygenase
Ligand
BDBM50293103
Substrate
n/a
Meas. Tech.
ChEMBL_514916 (CHEMBL972642)
IC50
2800±n/a nM
Citation
 Auld, DS; Zhang, YQ; Southall, NT; Rai, G; Landsman, M; MacLure, J; Langevin, D; Thomas, CJ; Austin, CP; Inglese, J A basis for reduced chemical library inhibition of firefly luciferase obtained from directed evolution. J Med Chem 52:1450-8 (2010) [PubMed]  Article 
Target
Name:
Luciferin 4-monooxygenase
Synonyms:
LUCI_PHOPY | Luciferase
Type:
PROTEIN
Mol. Mass.:
60747.46
Organism:
Photinus pyralis
Description:
ChEMBL_938513
Residue:
550
Sequence:
MEDAKNIKKGPAPFYPLEDGTAGEQLHKAMKRYALVPGTIAFTDAHIEVNITYAEYFEMSVRLAEAMKRYGLNTNHRIVVCSENSLQFFMPVLGALFIGVAVAPANDIYNERELLNSMNISQPTVVFVSKKGLQKILNVQKKLPIIQKIIIMDSKTDYQGFQSMYTFVTSHLPPGFNEYDFVPESFDRDKTIALIMNSSGSTGLPKGVALPHRTACVRFSHARDPIFGNQIIPDTAILSVVPFHHGFGMFTTLGYLICGFRVVLMYRFEEELFLRSLQDYKIQSALLVPTLFSFFAKSTLIDKYDLSNLHEIASGGAPLSKEVGEAVAKRFHLPGIRQGYGLTETTSAILITPEGDDKPGAVGKVVPFFEAKVVDLDTGKTLGVNQRGELCVRGPMIMSGYVNNPEATNALIDKDGWLHSGDIAYWDEDEHFFIVDRLKSLIKYKGYQVAPAELESILLQHPNIFDAGVAGLPDDDAGELPAAVVVLEHGKTMTEKEIVDYVASQVTTAKKLRGGVVFVDEVPKGLTGKLDARKIREILIKAKKGGKSKL
  
Inhibitor
Name:
BDBM50293103
Synonyms:
5-(2-fluorophenyl)-3-(4-methoxyphenyl)-1,2,4-oxadiazole | CHEMBL472929 | cid_925735
Type:
Small organic molecule
Emp. Form.:
C15H11FN2O2
Mol. Mass.:
270.2584
SMILES:
COc1ccc(cc1)-c1noc(n1)-c1ccccc1F
Structure:
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