Reaction Details Report a problem with these data
Target
Proto-oncogene Wnt-3
Ligand
BDBM50294789
Substrate
n/a
Meas. Tech.
ChEMBL_576549 (CHEMBL1032002)
EC50
1000±n/a nM
Citation
Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C Structure-activity relationship studies of small-molecule inhibitors of Wnt response. Bioorg Med Chem Lett 19:3825-7 (2009) [PubMed] Article
More Info.:
Target
Name:
Proto-oncogene Wnt-3
Synonyms:
INT4 | Proto-oncogene protein Wnt-3 | WNT3 | WNT3_HUMAN
Type:
PROTEIN
Mol. Mass.:
39653.31
Organism:
Homo sapiens (Human)
Description:
ChEMBL_576549
Residue:
355
Sequence:
MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK
Inhibitor
Name:
BDBM50294789
Synonyms:
4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-N-(2-methoxy-phenyl)-benzamide | CHEMBL550442
Type:
Small organic molecule
Emp. Form.:
C23H20N2O4
Mol. Mass.:
388.4159
SMILES:
COc1ccccc1NC(=O)c1ccc(cc1)-n1c(O)c2[C@H]3C[C@H](C=C3)c2c1O |r,c:26|