Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM50020221
Substrate
n/a
Meas. Tech.
ChEMBL_576760 (CHEMBL1032027)
Ki
1.36±n/a nM
Citation
 Brown, DA; Mishra, M; Zhang, S; Biswas, S; Parrington, I; Antonio, T; Reith, ME; Dutta, AK Investigation of various N-heterocyclic substituted piperazine versions of 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol: effect on affinity and selectivity for dopamine D3 receptor. Bioorg Med Chem 17:3923-33 (2009) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3
Type:
Protein
Mol. Mass.:
49540.58
Organism:
Rattus norvegicus (Rat)
Description:
P19020
Residue:
446
Sequence:
MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50020221
Synonyms:
(-)-5-hydroxy-2-(dipropylamino)tetralin | (-)-6-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol | 5-hydroxy-2-(dipropylamino)tetralin | 6-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol | 6-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol (DP-5-ADTN) | CHEMBL273273
Type:
Small organic molecule
Emp. Form.:
C16H25NO
Mol. Mass.:
247.3758
SMILES:
CCCN(CCC)C1CCc2c(O)cccc2C1
Structure:
Search PDB for entries with ligand similarity: