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Target
Neuromedin-B receptor
Ligand
BDBM50295254
Substrate
n/a
Meas. Tech.
ChEMBL_577514 (CHEMBL1057866)
IC50
170±n/a nM
Citation
 Fu, J; Shuttleworth, SJ; Connors, RV; Chai, A; Coward, P Discovery and optimization of a novel Neuromedin B receptor antagonist. Bioorg Med Chem Lett 19:4264-7 (2009) [PubMed]  Article 
Target
Name:
Neuromedin-B receptor
Synonyms:
Bombesin 1 | NMB-R | NMBR | NMBR_HUMAN | Neuromedin B | Neuromedin B receptor | Neuromedin-B receptor | Neuromedin-B-preferring bombesin receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43447.11
Organism:
Homo sapiens (Human)
Description:
Bombesin 1 NMBR 0::P28336
Residue:
390
Sequence:
MPSKSLSNLSVTTGANESGSVPEGWERDFLPASDGTTTELVIRCVIPSLYLLIITVGLLGNIMLVKIFITNSAMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWMFGKVGCKLIPVIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGALLRTCVKAMGIWVVSVLLAVPEAVFSEVARISSLDNSSFTACIPYPQTDELHPKIHSVLIFLVYFLIPLAIISIYYYHIAKTLIKSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFIFCWFPNHILYMYRSFNYNEIDPSLGHMIVTLVARVLSFGNSCVNPFALYLLSESFRRHFNSQLCCGRKSYQERGTSYLLSSSAVRMTSLKSNAKNMVTNSVLLNGHSMKQEMAL
  
Inhibitor
Name:
BDBM50295254
Synonyms:
11-(2-chloro-6-fluorophenyl)-3,3,8,10-tetramethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one | CHEMBL563564
Type:
Small organic molecule
Emp. Form.:
C23H24ClFN2O
Mol. Mass.:
398.901
SMILES:
CN1C(C2C(=O)CC(C)(C)CC2=Nc2ccc(C)cc12)c1c(F)cccc1Cl |c:12|
Structure:
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