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Target
Glycogen phosphorylase, muscle form
Ligand
BDBM50295313
Substrate
n/a
Meas. Tech.
ChEMBL_578067 (CHEMBL1051629)
Ki
1800000±n/a nM
Citation
 Nagy, V; Benltifa, M; Vidal, S; Berzsényi, E; Teilhet, C; Czifrák, K; Batta, G; Docsa, T; Gergely, P; Somsák, L; Praly, JP Glucose-based spiro-heterocycles as potent inhibitors of glycogen phosphorylase. Bioorg Med Chem 17:5696-707 (2009) [PubMed]  Article 
Target
Name:
Glycogen phosphorylase, muscle form
Synonyms:
Glycogen Phosphorylase (PYGM) | Glycogen phosphorylase a (RMGPa) | Glycogen phosphorylase, muscle form | Myophosphorylase | PYGM | PYGM_RABIT
Type:
Enzyme
Mol. Mass.:
97296.32
Organism:
Oryctolagus cuniculus (rabbit)
Description:
Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A.
Residue:
843
Sequence:
MSRPLSDQEKRKQISVRGLAGVENVTELKKNFNRHLHFTLVKDRNVATPRDYYFALAHTVRDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALENACDEATYQLGLDMEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKICGGWQMEEADDWLRYGNPWEKARPEFTLPVHFYGRVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVNTMRLWSAKAPNDFNLKDFNVGGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGCRDPVRTNFDAFPDKVAIQLNDTHPSLAIPELMRVLVDLERLDWDKAWEVTVKTCAYTNHTVLPEALERWPVHLLETLLPRHLQIIYEINQRFLNRVAAAFPGDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKFQNKTNGITPRRWLVLCNPGLAEIIAERIGEEYISDLDQLRKLLSYVDDEAFIRDVAKVKQENKLKFAAYLEREYKVHINPNSLFDVQVKRIHEYKRQLLNCLHVITLYNRIKKEPNKFVVPRTVMIGGKAAPGYHMAKMIIKLITAIGDVVNHDPVVGDRLRVIFLENYRVSLAEKVIPAADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVDRLDQRGYNAQEYYDRIPELRQIIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYEEYVKCQERVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPAPDEKIP
  
Inhibitor
Name:
BDBM50295313
Synonyms:
CHEMBL550360 | N-(beta-D-Glucopyranosyl)-4-cyanobenzamidoxime
Type:
Small organic molecule
Emp. Form.:
C14H17N3O6
Mol. Mass.:
323.3013
SMILES:
OC[C@H]1O[C@@H](N=C(NO)c2ccc(cc2)C#N)[C@H](O)[C@@H](O)[C@@H]1O |r,w:6.6|
Structure:
Search PDB for entries with ligand similarity: