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Target
Melatonin receptor type 1A
Ligand
BDBM50295869
Substrate
n/a
Meas. Tech.
ChEMBL_578756 (CHEMBL1052329)
IC50
3.14±n/a nM
Citation
 Markl, C; Attia, MI; Julius, J; Sethi, S; Witt-Enderby, PA; Zlotos, DP Synthesis and pharmacological evaluation of 1,2,3,4-tetrahydropyrazino[1,2-a]indole and 2-[(phenylmethylamino)methyl]-1H-indole analogues as novel melatoninergic ligands. Bioorg Med Chem 17:4583-94 (2009) [PubMed]  Article 
Target
Name:
Melatonin receptor type 1A
Synonyms:
MTNR1A | MTNR1A protein | MTR1A_HUMAN | Mel-1A-R | Mel1a melatonin receptor | Melatonin 1A | Melatonin receptor | Melatonin receptor 1A | Melatonin receptor type 1 (MT1) | Melatonin receptor type 1A
Type:
Enzyme
Mol. Mass.:
39392.94
Organism:
Homo sapiens (Human)
Description:
P48039
Residue:
350
Sequence:
MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFAQSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV
  
Inhibitor
Name:
BDBM50295869
Synonyms:
CHEMBL556908 | N-[2-(8-Methoxy-2-methyl-1,2,3,4-tetrahydropyrazino[1,2-a]indol-10-yl)ethyl]butanamide
Type:
Small organic molecule
Emp. Form.:
C19H27N3O2
Mol. Mass.:
329.4366
SMILES:
CCCC(=O)NCCc1c2CN(C)CCn2c2ccc(OC)cc12
Structure:
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