Reaction Details Report a problem with these data
Target
Heat shock factor protein 1
Ligand
BDBM50296068
Substrate
n/a
Meas. Tech.
ChEMBL_579378 (CHEMBL1063219)
EC50
4100±n/a nM
Citation
 Zhou, Y; Wei, L; Brady, TP; Murali Mohan Redddy, PS; Nguyen, T; Chen, J; Au, Q; Yoon, IS; Yip, G; Zhang, B; Barber, JR; Ng, SC Pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione derivatives as novel small molecule chaperone amplifiers. Bioorg Med Chem Lett 19:4303-7 (2009) [PubMed]  Article 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1 | HSF1_HUMAN | HSTF1
Type:
PROTEIN
Mol. Mass.:
57244.20
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1512556
Residue:
529
Sequence:
MDLPVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTKLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLNDSGSAHSMPKYSRQFSLEHVHGSGPYSAPSPAYSSSSLYAPDAVASSGPIISDITELAPASPMASPGGSIDERPLSSSPLVRVKEEPPSPPQSPRVEEASPGRPSSVDTLLSPTALIDSILRESEPAPASVTALTDARGHTDTEGRPPSPPPTSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHYTAQPLFLLDPGSVDTGSNDLPVLFELGEGSYFSEGDGFAEDPTISLLTGSEPPKAKDPTVS
  
Inhibitor
Name:
BDBM50296068
Synonyms:
3-(benzo[d]thiazol-2-yl)-1-benzyl-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione | CHEMBL565134
Type:
Small organic molecule
Emp. Form.:
C20H14N6O2S
Mol. Mass.:
402.429
SMILES:
Cn1c(=O)nc2n(Cc3ccccc3)nc(nc2c1=O)-c1nc2ccccc2s1
Structure:
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