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Target
Cathepsin D
Ligand
BDBM50298201
Substrate
n/a
Meas. Tech.
ChEMBL_585497 (CHEMBL1059231)
IC50
>100000±n/a nM
Citation
 Yamaguchi, Y; Menear, K; Cohen, NC; Mah, R; Cumin, F; Schnell, C; Wood, JM; Maibaum, J The P1N-isopropyl motif bearing hydroxyethylene dipeptide isostere analogues of aliskiren are in vitro potent inhibitors of the human aspartyl protease renin. Bioorg Med Chem Lett 19:4863-7 (2009) [PubMed]  Article 
Target
Name:
Cathepsin D
Synonyms:
CATD_BOVIN | CTSD
Type:
PROTEIN
Mol. Mass.:
42158.92
Organism:
Bos taurus
Description:
ChEMBL_1458606
Residue:
387
Sequence:
VIRIPLHKFTSIRRTMSEAAGVLIAKGPISKYATGEPAVRQGPIPELLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSANLWVPSIHCKLLDIACWTHRKYNSDKSSTYVKNGTTFDIHYGSGSLSGYLSQDTVSVPCNPSSSSPGGVTVQRQTFGEAIKQPGVVFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDKNVFSFFLNRDPKAQPGGELMLGGTDSKYYRGSLMFHNVTRQAYWQIHMDQLDVGSSLTVCKGGCEAIVDTGTSLIVGPVEEVRELQKAIGAVPLIQGEYMIPCEKVSSLPEVTVKLGGKDYALSPEDYALKVSQAETTVCLSGFMGMDIPPPGGPLWILGDVFIGRYYTVFDRDQNRVGLAEAARL
  
Inhibitor
Name:
BDBM50298201
Synonyms:
(2R,4S,5S)-5-amino-N-butyl-4-hydroxy-6-(N-isopropyl-4-methoxy-3-(3-methoxypropoxy)phenylsulfonamido)-2-methylhexanamide | CHEMBL560085
Type:
Small organic molecule
Emp. Form.:
C25H45N3O7S
Mol. Mass.:
531.706
SMILES:
CCCCNC(=O)[C@H](C)C[C@H](O)[C@@H](N)CN(C(C)C)S(=O)(=O)c1ccc(OC)c(OCCCOC)c1 |r|
Structure:
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