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Target
Oxysterols receptor LXR-beta
Ligand
BDBM50298699
Substrate
n/a
Meas. Tech.
ChEMBL_587934 (CHEMBL1046607)
IC50
7600±n/a nM
Citation
 Motoshima, K; Noguchi-Yachide, T; Sugita, K; Hashimoto, Y; Ishikawa, M Separation of alpha-glucosidase-inhibitory and liver X receptor-antagonistic activities of phenethylphenyl phthalimide analogs and generation of LXRalpha-selective antagonists. Bioorg Med Chem 17:5001-14 (2009) [PubMed]  Article 
Target
Name:
Oxysterols receptor LXR-beta
Synonyms:
LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50978.79
Organism:
Homo sapiens (Human)
Description:
P55055
Residue:
460
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM50298699
Synonyms:
CHEMBL575664 | N-{3-[2-(3,4-Dihydroxyphenyl)ethyl]phenyl}phthalimide
Type:
Small organic molecule
Emp. Form.:
C22H17NO4
Mol. Mass.:
359.3747
SMILES:
Oc1ccc(CCc2cccc(c2)N2C(=O)c3ccccc3C2=O)cc1O
Structure:
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