Reaction Details Report a problem with these data
Target
Ephrin type-B receptor 4
Ligand
BDBM50299220
Substrate
n/a
Meas. Tech.
ChEMBL_592561 (CHEMBL1046768)
IC50
213±n/a nM
Citation
 Lafleur, K; Huang, D; Zhou, T; Caflisch, A; Nevado, C Structure-based optimization of potent and selective inhibitors of the tyrosine kinase erythropoietin producing human hepatocellular carcinoma receptor B4 (EphB4). J Med Chem 52:6433-46 (2009) [PubMed]  Article 
Target
Name:
Ephrin type-B receptor 4
Synonyms:
EPHB4 | EPHB4_HUMAN | Ephrin receptor | Ephrin type-B receptor 4 precursor (Tyrosine-protein kinase receptor HTK). | HTK | Hepatoma transmembrane kinase | MYK1 | TYRO11 | Tyrosine-protein kinase TYRO11 | VHL/Ephrin type-B receptor 4
Type:
Enzyme
Mol. Mass.:
108273.51
Organism:
Homo sapiens (Human)
Description:
P54760
Residue:
987
Sequence:
MELRVLLCWASLAAALEETLLNTKLETADLKWVTFPQVDGQWEELSGLDEEQHSVRTYEVCDVQRAPGQAHWLRTGWVPRRGAVHVYATLRFTMLECLSLPRAGRSCKETFTVFYYESDADTATALTPAWMENPYIKVDTVAAEHLTRKRPGAEATGKVNVKTLRLGPLSKAGFYLAFQDQGACMALLSLHLFYKKCAQLTVNLTRFPETVPRELVVPVAGSCVVDAVPAPGPSPSLYCREDGQWAEQPVTGCSCAPGFEAAEGNTKCRACAQGTFKPLSGEGSCQPCPANSHSNTIGSAVCQCRVGYFRARTDPRGAPCTTPPSAPRSVVSRLNGSSLHLEWSAPLESGGREDLTYALRCRECRPGGSCAPCGGDLTFDPGPRDLVEPWVVVRGLRPDFTYTFEVTALNGVSSLATGPVPFEPVNVTTDREVPPAVSDIRVTRSSPSSLSLAWAVPRAPSGAVLDYEVKYHEKGAEGPSSVRFLKTSENRAELRGLKRGASYLVQVRARSEAGYGPFGQEHHSQTQLDESEGWREQLALIAGTAVVGVVLVLVVIVVAVLCLRKQSNGREAEYSDKHGQYLIGHGTKVYIDPFTYEDPNEAVREFAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALDKMIRNPASLKIVARENGGASHPLLDQRQPHYSAFGSVGEWLRAIKMGRYEESFAAAGFGSFELVSQISAEDLLRIGVTLAGHQKKILASVQHMKSQAKPGTPGGTGGPAPQY
  
Inhibitor
Name:
BDBM50299220
Synonyms:
8-(2-Methoxyphenyl)-1-methyl-7-m-hydroxyphenyl-1H-imidazo-[2,1-f]purine-2,4(3H,8H)-dione | CHEMBL575335
Type:
Small organic molecule
Emp. Form.:
C21H17N5O4
Mol. Mass.:
403.3908
SMILES:
COc1ccccc1-n1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1cccc(O)c1 |(15.4,-17.54,;15.41,-16,;16.74,-15.23,;18.07,-16,;19.4,-15.23,;19.39,-13.69,;18.06,-12.93,;16.75,-13.7,;15.42,-12.93,;15.42,-11.39,;13.96,-10.9,;13.05,-12.15,;13.95,-13.4,;13.05,-14.64,;11.58,-14.17,;10.25,-14.93,;10.25,-16.47,;8.92,-14.16,;7.59,-14.94,;8.92,-12.62,;10.25,-11.85,;10.25,-10.31,;11.58,-12.62,;16.75,-10.61,;16.74,-9.08,;18.06,-8.3,;19.41,-9.06,;19.42,-10.6,;20.76,-11.36,;18.09,-11.38,)|
Structure:
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