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Target
Tyrosine-protein phosphatase non-receptor type 2
Ligand
BDBM50299736
Substrate
n/a
Meas. Tech.
ChEMBL_588940 (CHEMBL1063855)
IC50
5.51E3±n/a nM
Citation
 Qiu, WW; Shen, Q; Yang, F; Wang, B; Zou, H; Li, JY; Li, J; Tang, J Synthesis and biological evaluation of heterocyclic ring-substituted maslinic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B. Bioorg Med Chem Lett 19:6618-22 (2009) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 2
Synonyms:
PTN2_HUMAN | PTPN2 | PTPT | T-cell protein tyrosine phosphatase (TCPTP) | T-cell protein-tyrosine phosphatase | TC-PTP | TCPTP | Tyrosine-protein phosphatase non-receptor type 2 | Tyrosine-protein phosphatase non-receptor type 2 (TC-PTP)
Type:
Protein
Mol. Mass.:
48481.80
Organism:
Homo sapiens (Human)
Description:
P17706
Residue:
415
Sequence:
MPTTIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPAFDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKATTAQKVQQMKQRLNENERKRKRWLYWQPILTKMGFMSVILVGAFVGWTLFFQQNAL
  
Inhibitor
Name:
BDBM50299736
Synonyms:
(4aS,6aS,6bR,8aR,14aR,14bR,16bS)-11-amino-2,2,6a,6b,9,9,14a-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,14,14a,14b,15,16b-octadecahydrochryseno[1,2-g]quinazoline-4a-carboxylic acid | CHEMBL573496
Type:
Small organic molecule
Emp. Form.:
C32H47N3O2
Mol. Mass.:
505.7345
SMILES:
CC1(C)CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)Cc6cnc(N)nc6C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2C1)C(O)=O |r,c:10|
Structure:
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