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Target
Mitogen-activated protein kinase 11
Ligand
BDBM50302943
Substrate
n/a
Meas. Tech.
ChEMBL_596155 (CHEMBL1044494)
IC50
5400±n/a nM
Citation
 Li, J; Kaoud, TS; Laroche, C; Dalby, KN; Kerwin, SM Synthesis and biological evaluation of p38alpha kinase-targeting dialkynylimidazoles. Bioorg Med Chem Lett 19:6293-7 (2009) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 11
Synonyms:
MAP kinase p38 | MAPK11 | MK11_HUMAN | Mitogen-activated protein kinase 11 | Mitogen-activated protein kinase p38 beta | PRKM11 | SAPK2 | SAPK2B | Stress-activated protein kinase 2 | p38 MAP kinase alpha/beta | p38-2 | p38-beta | p38b
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41351.73
Organism:
Homo sapiens (Human)
Description:
gi_20128774
Residue:
364
Sequence:
MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPPEPPKPPGSLEIEQ
  
Inhibitor
Name:
BDBM50302943
Synonyms:
4-(4-fluorophenyl)-5-(4-pyridyl)-1-(ethynyl)-2-(but-3-yn-1-ol)-1H-imidazole | CHEMBL576620
Type:
Small organic molecule
Emp. Form.:
C20H14FN3O
Mol. Mass.:
331.3431
SMILES:
OCCC#Cc1nc(c(-c2ccncc2)n1C#C)-c1ccc(F)cc1
Structure:
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