Reaction Details
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DNA-(apurinic or apyrimidinic site) endonuclease
Ligand
BDBM50303958
Substrate
n/a
Meas. Tech.
ChEMBL_595225 (CHEMBL1043577)
IC50
15000±n/a nM
Citation
Nyland, RL; Luo, M; Kelley, MR; Borch, RF Design and synthesis of novel quinone inhibitors targeted to the redox function of apurinic/apyrimidinic endonuclease 1/redox enhancing factor-1 (Ape1/ref-1). J Med Chem 53:1200-10 (2010) [PubMed] Article More Info.:
Target
Name:
DNA-(apurinic or apyrimidinic site) endonuclease
Synonyms:
APE | APE1 | APEX | APEX1 | APEX1_HUMAN | APX | Apurinic-apyrimidinic endonuclease 1 (APE-1) | Apurinic/apyrimidinic endonuclease 1 (APE1) | DNA-(apurinic or apyrimidinic site) lyase | HAP1 | REF1
Type:
Protein
Mol. Mass.:
35560.12
Organism:
Homo sapiens (Human)
Description:
P27695
Residue:
318
Sequence:
MPKRGKKGAVAEDGDELRTEPEAKKSKTAAKKNDKEAAGEGPALYEDPPDQKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWSAPSDKEGYSGVGLLSRQCPLKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLVRLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGFGELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKIRSKALGSDHCPITLYLAL
Inhibitor
Name:
BDBM50303958
Synonyms:
(E)-3-(5,6-Dimethoxy-3-methyl-1,4-dioxocyclohexa-2,5-dienyl)-2-butylpropenoic Acid | CHEMBL571827
Type:
Small organic molecule
Emp. Form.:
C16H20O6
Mol. Mass.:
308.3264
SMILES:
CCCCC(=CC1=C(C)C(=O)C(OC)=C(OC)C1=O)C(O)=O |w:5.5,c:6,t:13|
Structure:
