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Target
Cytosolic endo-beta-N-acetylglucosaminidase
Ligand
BDBM50304532
Substrate
n/a
Meas. Tech.
ChEMBL_604110 (CHEMBL1041618)
Ki
1.25±n/a nM
Citation
 Usuki, H; Toyo-oka, M; Kanzaki, H; Okuda, T; Nitoda, T Pochonicine, a polyhydroxylated pyrrolizidine alkaloid from fungus Pochonia suchlasporia var. suchlasporia TAMA 87 as a potent beta-N-acetylglucosaminidase inhibitor. Bioorg Med Chem 17:7248-53 (2009) [PubMed]  Article 
Target
Name:
Cytosolic endo-beta-N-acetylglucosaminidase
Synonyms:
ENASE_HUMAN | ENGASE | Endo-beta-N-acetylglucosaminidase
Type:
PROTEIN
Mol. Mass.:
83989.32
Organism:
Homo sapiens (Human)
Description:
ChEMBL_467019
Residue:
743
Sequence:
MEAAAVTVTRSATRRRRRQLQGLAAPEAGTQEEQEDQEPRPRRRRPGRSIKDEEEETVFREVVSFSPDPLPVRYYDKDTTKPISFYLSSLEELLAWKPRLEDGFNVALEPLACRQPPLSSQRPRTLLCHDMMGGYLDDRFIQGSVVQTPYAFYHWQCIDVFVYFSHHTVTIPPVGWTNTAHRHGVCVLGTFITEWNEGGRLCEAFLAGDERSYQAVADRLVQITQFFRFDGWLINIENSLSLAAVGNMPPFLRYLTTQLHRQVPGGLVLWYDSVVQSGQLKWQDELNQHNRVFFDSCDGFFTNYNWREEHLERMLGQAGERRADVYVGVDVFARGNVVGGRFDTDKSLELIRKHGFSVALFAPGWVYECLEKKDFFQNQDKFWGRLERYLPTHSICSLPFVTSFCLGMGARRVCYGQEEAVGPWYHLSAQEIQPLFGEHRLGGDGRGWVRTHCCLEDAWHGGSSLLVRGVIPPEVGNVAVRLFSLQAPVPPKIYLSMVYKLEGPTDVTVALELTTGDAGSCHIGGISVLNAETSSRHSLRPLRVPPTKLARWVGRCGRQLSGGWVQHCYEVSLRGCLLLDLLVCFSRPPGSREEESFTCRLGEIQVVDAASLLAPLPQVQAVTISHIRWQPSASEREGPPALLQLSCTLHWSFLLSQVRCFRIHCWGGMSDDSPGRELPRPEMPMFLGLAFATQYRIVDLLVEAAGPGQDRRMEFLVEPVPKEGFRVPQAEWGRAVLLYSAPA
  
Inhibitor
Name:
BDBM50304532
Synonyms:
(1R*, 3S*, 5S*, 6S*, 7R*, 7a S*)-5-acetamidomethyl-3-hydroxymethyl-1,6,7-trihydroxypyrrolizidine | CHEMBL593689
Type:
Small organic molecule
Emp. Form.:
C11H20N2O5
Mol. Mass.:
260.2869
SMILES:
CC(=O)NC[C@H]1[C@H](O)[C@H](O)[C@@H]2[C@H](O)C[C@@H](CO)N12 |r|
Structure:
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