Reaction Details Report a problem with these data
Target
Renin
Ligand
BDBM50305446
Substrate
n/a
Meas. Tech.
ChEMBL_603747 (CHEMBL1039372)
IC50
31±n/a nM
Citation
Xu, Z; Cacatian, S; Yuan, J; Simpson, RD; Jia, L; Zhao, W; Tice, CM; Flaherty, PT; Guo, J; Ishchenko, A; Singh, SB; Wu, Z; McKeever, BM; Scott, BB; Bukhtiyarov, Y; Berbaum, J; Mason, J; Panemangalore, R; Cappiello, MG; Bentley, R; Doe, CP; Harrison, RK; McGeehan, GM; Dillard, LW; Baldwin, JJ; Claremon, DA Optimization of orally bioavailable alkyl amine renin inhibitors. Bioorg Med Chem Lett 20:694-9 (2010) [PubMed] Article
More Info.:
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
Inhibitor
Name:
BDBM50305446
Synonyms:
(R)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-4-ureidobutyl)-N-((S)-1-cyclohexyl-3-(methylamino)propan-2-yl)piperidine-1-carboxamide | CHEMBL592048
Type:
Small organic molecule
Emp. Form.:
C27H44ClN5O3
Mol. Mass.:
522.123
SMILES:
CNC[C@H](CC1CCCCC1)NC(=O)N1CCC[C@H](C1)[C@@](O)(CCCNC(N)=O)c1cccc(Cl)c1 |r|