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Target
Oxysterols receptor LXR-beta
Ligand
BDBM50305489
Substrate
n/a
Meas. Tech.
ChEMBL_604017 (CHEMBL1049545)
IC50
590±n/a nM
Citation
 Hu, B; Bernotas, R; Unwalla, R; Collini, M; Quinet, E; Feingold, I; Goos-Nilsson, A; Wilhelmsson, A; Nambi, P; Evans, M; Wrobel, J Quinoline-3-carboxamide containing sulfones as liver X receptor (LXR) agonists with binding selectivity for LXRbeta and low blood-brain penetration. Bioorg Med Chem Lett 20:689-93 (2010) [PubMed]  Article 
Target
Name:
Oxysterols receptor LXR-beta
Synonyms:
LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50978.79
Organism:
Homo sapiens (Human)
Description:
P55055
Residue:
460
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM50305489
Synonyms:
8-fluoro-4-(3-(3-(methylsulfonyl)phenoxy)phenyl)quinoline-3-carboxamide | CHEMBL593740
Type:
Small organic molecule
Emp. Form.:
C23H17FN2O4S
Mol. Mass.:
436.455
SMILES:
CS(=O)(=O)c1cccc(Oc2cccc(c2)-c2c(cnc3c(F)cccc23)C(N)=O)c1
Structure:
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