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Target
Acyl-CoA desaturase 1
Ligand
BDBM50305753
Substrate
n/a
Meas. Tech.
ChEMBL_604760 (CHEMBL1072554)
IC50
62±n/a nM
Citation
 Léger, S; Black, WC; Deschenes, D; Dolman, S; Falgueyret, JP; Gagnon, M; Guiral, S; Huang, Z; Guay, J; Leblanc, Y; Li, CS; Massé, F; Oballa, R; Zhang, L Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438). Bioorg Med Chem Lett 20:499-502 (2010) [PubMed]  Article 
Target
Name:
Acyl-CoA desaturase 1
Synonyms:
ACOD1_RAT | Acyl-CoA desaturase 1 | Scd | Scd1 | Stearoyl-CoA desaturase 1 (SCD1)
Type:
Enzyme
Mol. Mass.:
41485.97
Organism:
Rattus norvegicus (Rat)
Description:
P07308
Residue:
358
Sequence:
MPAHMLQEISSSYTTTTTITEPPSGNLQNGREKMKKVPLYLEEDIRPEMREDIHDPSYQDEEGPPPKLEYVWRNIILMALLHVGALYGITLIPSSKVYTLLWGIFYYLISALGITAGAHRLWSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGETFLHSLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYHHAFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAVLARIKRTGDGSHKSS
  
Inhibitor
Name:
BDBM50305753
Synonyms:
3-(4-(2,3-dihydro-1H-inden-5-yloxy)piperidin-1-yl)-6-(1H-imidazol-1-yl)pyridazine | CHEMBL603324
Type:
Small organic molecule
Emp. Form.:
C21H23N5O
Mol. Mass.:
361.4402
SMILES:
C1Cc2ccc(OC3CCN(CC3)c3ccc(nn3)-n3ccnc3)cc2C1
Structure:
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