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Target
Monoacylglycerol lipase ABHD6
Ligand
BDBM50307081
Substrate
n/a
Meas. Tech.
ChEMBL_609360 (CHEMBL1072746)
IC50
180±n/a nM
Citation
 Long, JZ; Jin, X; Adibekian, A; Li, W; Cravatt, BF Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases. J Med Chem 53:1830-42 (2010) [PubMed]  Article 
Target
Name:
Monoacylglycerol lipase ABHD6
Synonyms:
ABHD6_MOUSE | Abh6 | Abhd6 | Abhydrolase Domain-Containing Protein 6 | Monoacylglycerol lipase ABHD6
Type:
Single-pass type II membrane protein; hydrolase
Mol. Mass.:
38216.17
Organism:
Mus musculus (mouse)
Description:
Assays were using membranes of recombinant Abh6 transiently transfected in COS-7 cells.
Residue:
336
Sequence:
MDLDVVNMFVIAGGTLAIPILAFVASFLLWPSALIRIYYWYWRRTLGMQVRYAHHEDYQFCYSFRGRPGHKPSILMLHGFSAHKDMWLSVVKFLPKNLHLVCVDMPGHEGTTRSSLDDLSIVGQVKRIHQFVECLKLNKKPFHLIGTSMGGHVAGVYAAYYPSDVCSLSLVCPAGLQYSTDNPFVQRLKELEESAAIQKIPLIPSTPEEMSEMLQLCSYVRFKVPQQILQGLVDVRIPHNSFYRKLFLEIVNEKSRYSLHENMDKIKVPTQIIWGKQDQVLDVSGADILAKSISNSQVEVLENCGHSVVMERPRKTAKLIVDFLASVHNTDNKKLN
  
Inhibitor
Name:
BDBM50307081
Synonyms:
4-Nitrophenyl 4-((5-(2-(Trifluoromethoxy)phenyl)furan-2-yl)methyl)piperazine-1-carboxylate | CHEMBL604948
Type:
Small organic molecule
Emp. Form.:
C23H20F3N3O6
Mol. Mass.:
491.4166
SMILES:
[O-][N+](=O)c1ccc(OC(=O)N2CCN(Cc3ccc(o3)-c3ccccc3OC(F)(F)F)CC2)cc1
Structure:
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