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Target
Amine oxidase [flavin-containing] B
Ligand
BDBM50307198
Substrate
n/a
Meas. Tech.
ChEMBL_610339 (CHEMBL1072071)
IC50
65000±n/a nM
Citation
 Shi, L; Yang, Y; Li, ZL; Zhu, ZW; Liu, CH; Zhu, HL Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors. Bioorg Med Chem 18:1659-64 (2010) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
AOFB_RAT | Amine oxidase (flavin-containing) B | Amine oxidase [flavin-containing] B | Maob | Monoamine Oxidase Type B (MAO-B) | Monoamine oxidase | Monoamine oxidase B (MAO-B) | Monoamine oxidase B (rMAO-B) | Monoamine oxidase type B (MAOB) | Monoamine oxidase-B (MAO-B)
Type:
Enzyme
Mol. Mass.:
58469.65
Organism:
Rattus norvegicus (rat)
Description:
P19643
Residue:
520
Sequence:
MSNKCDVIVVGGGISGMAAAKLLHDCGLSVVVLEARDRVGGRTYTIRNKNVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHFVKGKSYAFRGPFPPVWNPITYLDYNNLWRTMDEMGQEIPSDAPWKAPLAEEWDYMTMKELLDKICWTNSTKQIATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFIGGSGQVSERIKDILGDRVKLERPVIHIDQTGENVVVKTLNHEIYEAKYVISAIPPVLGMKIHHSPPLPILRNQLITRVPLGSVIKCMVYYKEPFWRKKDFCGTMVIEGEEAPIAYTLDDTKPDGSCAAIMGFILAHKARKLVRLTKEERLRKLCELYAKVLNSQEALQPVHYEEKNWCEEQYSGGCYTAYFPPGILTQYGRVLRQPVGKIFFAGTETASHWSGYMEGAVEAGERAAREILHAIGKIPEDEIWQPEPESVDVPARPITNTFLERHLPSVPGLLKLLGLTTILSATALGFLAHKKGLFVRF
  
Inhibitor
Name:
BDBM50307198
Synonyms:
5-Bromo-N-(3-morpholinopropyl)nicotinamide | CHEMBL598587
Type:
Small organic molecule
Emp. Form.:
C13H18BrN3O2
Mol. Mass.:
328.205
SMILES:
Brc1cncc(c1)C(=O)NCCCN1CCOCC1
Structure:
Search PDB for entries with ligand similarity: