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Target
Amine oxidase [flavin-containing] A
Ligand
BDBM50307186
Substrate
n/a
Meas. Tech.
ChEMBL_610338 (CHEMBL1072070)
IC50
86000±n/a nM
Citation
 Shi, L; Yang, Y; Li, ZL; Zhu, ZW; Liu, CH; Zhu, HL Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors. Bioorg Med Chem 18:1659-64 (2010) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] A
Synonyms:
AOFA_RAT | Amine oxidase (flavin-containing) A | Amine oxidase [flavin-containing] A | Maoa | Monoamine Oxidase Type A (MAO-A) | Monoamine oxidase | Monoamine oxidase A (MAO-A) | Monoamine oxidase A (rMAO-A) | Monoamine oxidase type A (MAOA)
Type:
Enzyme
Mol. Mass.:
59515.21
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
526
Sequence:
MTDLEKPNLAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNINVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKLSSPVTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAKIHFKPELPPERNQLIQRLPMGAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITLDDTKPDGSLPAIMGFILARKADRQAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKVAKKDIWVEEPESKDVPAIEITHTFLERNLPSVPGLLKITGVSTSVALLCFVLYKIKKLPC
  
Inhibitor
Name:
BDBM50307186
Synonyms:
6-Methyl-N-(2-morpholinoethyl)nicotinamide | CHEMBL598189
Type:
Small organic molecule
Emp. Form.:
C13H19N3O2
Mol. Mass.:
249.3089
SMILES:
Cc1ccc(cn1)C(=O)NCCN1CCOCC1
Structure:
Search PDB for entries with ligand similarity: