Reaction Details Report a problem with these data
Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50146187
Substrate
n/a
Meas. Tech.
ChEMBL_613498 (CHEMBL1072264)
IC50
1970±n/a nM
Citation
 Pegklidou, K; Koukoulitsa, C; Nicolaou, I; Demopoulos, VJ Design and synthesis of novel series of pyrrole based chemotypes and their evaluation as selective aldose reductase inhibitors. A case of bioisosterism between a carboxylic acid moiety and that of a tetrazole. Bioorg Med Chem 18:2107-14 (2010) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1
Type:
PROTEIN
Mol. Mass.:
35797.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1512484
Residue:
316
Sequence:
MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV
  
Inhibitor
Name:
BDBM50146187
Synonyms:
(3-Benzoyl-pyrrol-1-yl)-acetic acid | 2-(3-benzoyl-1H-pyrrol-1-yl)acetic acid | CHEMBL93723
Type:
Small organic molecule
Emp. Form.:
C13H11NO3
Mol. Mass.:
229.2313
SMILES:
OC(=O)Cn1ccc(c1)C(=O)c1ccccc1
Structure:
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