Reaction Details Report a problem with these data
Target
Dipeptidyl peptidase 4
Ligand
BDBM50310548
Substrate
n/a
Meas. Tech.
ChEMBL_620095 (CHEMBL1109350)
IC50
1534±n/a nM
Citation
 Gupta, RC; Chhipa, L; Mandhare, AB; Zambad, SP; Chauthaiwale, V; Nadkarni, SS; Dutt, C Novel N-substituted 4-hydrazino piperidine derivative as a dipeptidyl peptidase IV inhibitor. Bioorg Med Chem Lett 19:5021-5 (2009) [PubMed]  Article 
Target
Name:
Dipeptidyl peptidase 4
Synonyms:
CD26 | CD_antigen=CD26 | DPP IV | DPP4 | DPP4_PIG | Dipeptidyl peptidase 4 | Dipeptidyl peptidase 4 membrane form | Dipeptidyl peptidase 4 soluble form | Dipeptidyl peptidase IV | Dipeptidyl peptidase IV membrane form | Dipeptidyl peptidase IV soluble form | T-cell activation antigen CD26
Type:
Enzyme
Mol. Mass.:
88235.21
Organism:
Sus scrofa (pig)
Description:
n/a
Residue:
766
Sequence:
MKTPWKVLLGLLGIAALVTVITVPVVLLNKGTDDAAADSRRTYTLTDYLKSTFRVKFYTLQWISDHEYLYKQENNILLFNAEYGNSSIFLENSTFDELGYSTNDYSVSPDRQFILFEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWITWSPVGHKLAYVWNNDIYVKNEPNLSSQRITWTGKENVIYNGVTDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRIPYPKAGAENPTVKFFVVDTRTLSPNASVTSYQIVPPASVLIGDHYLCGVTWVTEERISLQWIRRAQNYSIIDICDYDESTGRWISSVARQHIEISTTGWVGRFRPAEPHFTSDGNSFYKIISNEEGYKHICHFQTDKSNCTFITKGAWEVIGIEALTSDYLYYISNEHKGMPGGRNLYRIQLNDYTKVTCLSCELNPERCQYYSASFSNKAKYYQLRCFGPGLPLYTLHSSSSDKELRVLEDNSALDKMLQDVQMPSKKLDVINLHGTKFWYQMILPPHFDKSKKYPLLIEVYAGPCSQKVDTVFRLSWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEATRQFSKMGFVDDKRIAIWGWSYGGYVTSMVLGAGSGVFKCGIAVAPVSKWEYYDSVYTERYMGLPTPEDNLDYYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQLSKALVDAGVDFQTMWYTDEDHGIASNMAHQHIYTHMSHFLKQCFSLP
  
Inhibitor
Name:
BDBM50310548
Synonyms:
(R)-3-(2-(1-(1-acetylpiperidin-4-yl)hydrazinyl)acetyl)thiazolidine-4-carbonitrile 2,2,2-trifluoroacetate | CHEMBL1077838
Type:
Small organic molecule
Emp. Form.:
C13H21N5O2S
Mol. Mass.:
311.403
SMILES:
CC(=O)N1CCC(CC1)N(N)CC(=O)N1CSC[C@H]1C#N |r|
Structure:
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