Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 1
Ligand
BDBM50312007
Substrate
n/a
Meas. Tech.
ChEMBL_620603 (CHEMBL1112064)
Ki
248±n/a nM
Citation
 Sun, ZY; Zhu, Z; Ye, Y; McKittrick, B; Czarniecki, M; Greenlee, W; Mullins, D; Guzzi, M Discovery and SAR of cyclic isothioureas as novel NPY Y1 receptor antagonists. Bioorg Med Chem Lett 19:6801-5 (2009) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 1
Synonyms:
NPY-Y1 | NPY1-R | NPY1R | NPY1R_HUMAN | NPYR | NPYY1 | neuropeptide Y receptor Y1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44399.07
Organism:
Homo sapiens (Human)
Description:
NPY-Y1 NPY1R HUMAN::P25929
Residue:
384
Sequence:
MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI
  
Inhibitor
Name:
BDBM50312007
Synonyms:
CHEMBL1081469 | N-(4-(4,5-dihydrothiazol-2-ylamino)phenethyl)benzo[d]thiazol-2-amine
Type:
Small organic molecule
Emp. Form.:
C18H18N4S2
Mol. Mass.:
354.492
SMILES:
C(Cc1ccc(cc1)N=C1NCCS1)Nc1nc2ccccc2s1 |w:8.8|
Structure:
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