Reaction Details Report a problem with these data
Target
Acyl-CoA desaturase 1
Ligand
BDBM50312695
Substrate
n/a
Meas. Tech.
ChEMBL_615424 (CHEMBL1105109)
IC50
150±n/a nM
Citation
 Ramtohul, YK; Black, C; Chan, CC; Crane, S; Guay, J; Guiral, S; Huang, Z; Oballa, R; Xu, LJ; Zhang, L; Li, CS SAR and optimization of thiazole analogs as potent stearoyl-CoA desaturase inhibitors. Bioorg Med Chem Lett 20:1593-7 (2010) [PubMed]  Article 
Target
Name:
Acyl-CoA desaturase 1
Synonyms:
ACOD1_RAT | Acyl-CoA desaturase 1 | Scd | Scd1 | Stearoyl-CoA desaturase 1 (SCD1)
Type:
Enzyme
Mol. Mass.:
41485.97
Organism:
Rattus norvegicus (Rat)
Description:
P07308
Residue:
358
Sequence:
MPAHMLQEISSSYTTTTTITEPPSGNLQNGREKMKKVPLYLEEDIRPEMREDIHDPSYQDEEGPPPKLEYVWRNIILMALLHVGALYGITLIPSSKVYTLLWGIFYYLISALGITAGAHRLWSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGETFLHSLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYHHAFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAVLARIKRTGDGSHKSS
  
Inhibitor
Name:
BDBM50312695
Synonyms:
1-(2-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)thiazol-5-yl)urea | CHEMBL1081825
Type:
Small organic molecule
Emp. Form.:
C16H17F3N4O2S
Mol. Mass.:
386.392
SMILES:
NC(=O)Nc1cnc(s1)N1CCC(CC1)Oc1ccccc1C(F)(F)F
Structure:
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