Reaction Details Report a problem with these data
Target
Adenosine receptor A3
Ligand
BDBM50312966
Substrate
n/a
Meas. Tech.
ChEMBL_616403 (CHEMBL1100689)
Ki
3754±n/a nM
Citation
 Eastwood, P; Gonzalez, J; Paredes, S; Fonquerna, S; Cardús, A; Alonso, JA; Nueda, A; Domenech, T; Reinoso, RF; Vidal, B Discovery of potent and selective bicyclic A(2B) adenosine receptor antagonists via bioisosteric amide replacement. Bioorg Med Chem Lett 20:1634-7 (2010) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50312966
Synonyms:
CHEMBL1081971 | N-(6-(furan-2-yl)-5-(pyrimidin-4-yl)pyridin-2-yl)cyclopropanecarboxamide
Type:
Small organic molecule
Emp. Form.:
C17H14N4O2
Mol. Mass.:
306.3187
SMILES:
O=C(Nc1ccc(-c2ccncn2)c(n1)-c1ccco1)C1CC1
Structure:
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