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Target
Glycylpeptide N-tetradecanoyltransferase 1
Ligand
BDBM50313457
Substrate
n/a
Meas. Tech.
ChEMBL_617371 (CHEMBL1101882)
IC50
434000±n/a nM
Citation
 Jha, A; Mukherjee, C; Prasad, AK; Parmar, VS; Vadaparti, M; Das, U; De Clercq, E; Balzarini, J; Stables, JP; Shrivastav, A; Sharma, RK; Dimmock, JR Derivatives of aryl amines containing the cytotoxic 1,4-dioxo-2-butenyl pharmacophore. Bioorg Med Chem Lett 20:1510-5 (2010) [PubMed]  Article 
Target
Name:
Glycylpeptide N-tetradecanoyltransferase 1
Synonyms:
Myristoyl-CoA:protein N-myristoyltransferase (Nmt) | N-myristoyltransferase (NMT1) | NMT | NMT1 | NMT1_HUMAN | Peptide N-myristoyltransferase | Peptide N-myristoyltransferase 1
Type:
Enzyme
Mol. Mass.:
56814.10
Organism:
Homo sapiens (Human)
Description:
P30419
Residue:
496
Sequence:
MADESETAVKPPAPPLPQMMEGNGNGHEHCSDCENEEDNSYNRGGLSPANDTGAKKKKKKQKKKKEKGSETDSAQDQPVKMNSLPAERIQEIQKAIELFSVGQGPAKTMEEASKRSYQFWDTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLPQGFTWDALDLGDRGVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEKKMVEINFLCVHKKLRSKRVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTCRYWHRSLNPRKLIEVKFSHLSRNMTMQRTMKLYRLPETPKTAGLRPMETKDIPVVHQLLTRYLKQFHLTPVMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTLPSTIMNHPTHKSLKAAYSFYNVHTQTPLLDLMSDALVLAKMKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWKCPSMGAEKVGLVLQ
  
Inhibitor
Name:
BDBM50313457
Synonyms:
(Z)-4-(2,6-dimethylphenylamino)-4-oxobut-2-enoic acid | CHEMBL1079063
Type:
Small organic molecule
Emp. Form.:
C12H13NO3
Mol. Mass.:
219.2365
SMILES:
Cc1cccc(C)c1NC(=O)\C=C/C(O)=O
Structure:
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