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Target
Bombesin receptor subtype-3
Ligand
BDBM50313738
Substrate
n/a
Meas. Tech.
ChEMBL_614790 (CHEMBL1113309)
EC50
8±n/a nM
Citation
 He, S; Dobbelaar, PH; Liu, J; Jian, T; Sebhat, IK; Lin, LS; Goodman, A; Guo, C; Guzzo, PR; Hadden, M; Henderson, AJ; Ruenz, M; Sargent, BJ; Yet, L; Kelly, TM; Palyha, O; Kan, Y; Pan, J; Chen, H; Marsh, DJ; Shearman, LP; Strack, AM; Metzger, JM; Feighner, SD; Tan, C; Howard, AD; Tamvakopoulos, C; Peng, Q; Guan, XM; Reitman, ML; Patchett, AA; Wyvratt, MJ; Nargund, RP Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists. Bioorg Med Chem Lett 20:1913-7 (2010) [PubMed]  Article 
Target
Name:
Bombesin receptor subtype-3
Synonyms:
BRS3_MOUSE | Brs3
Type:
PROTEIN
Mol. Mass.:
44239.49
Organism:
Mus musculus
Description:
ChEMBL_1445902
Residue:
399
Sequence:
MSQRQSQSPNQTLISITNDTETSSSVVSNDTTHKGWTGDNSPGIEALCAIYITYAGIISVGILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGKVGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPPNAILKTCAKAGGIWIVSMIFALPEAIFSNVYTFQDPNRNVTFESCNSYPISERLLQEIHSLLCFLVFYIIPLSIISVYYSLIARTLYKSTLNIPTEEQSHARKQIESRKRIAKTVLVLVALFALCWLPNHLLYLYHSFTYESYANHSDVPFVIIIFSRVLAFSNSCVNPFALYWLSKTFQQHFKAQLCCLKAEQPEPPLGDIPLNNLTVMGRVPATGSAHVSEISVTLFSGSSAKKGEDKV
  
Inhibitor
Name:
BDBM50313738
Synonyms:
4'-(2-(5-(2,3-difluorobenzyl)-1H-imidazol-2-yl)ethyl)biphenyl-2-carboxylic acid | CHEMBL1084696
Type:
Small organic molecule
Emp. Form.:
C25H20F2N2O2
Mol. Mass.:
418.4353
SMILES:
OC(=O)c1ccccc1-c1ccc(CCc2ncc(Cc3cccc(F)c3F)[nH]2)cc1
Structure:
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