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Target
P2Y purinoceptor 1
Ligand
BDBM50315825
Substrate
n/a
Meas. Tech.
ChEMBL_626109 (CHEMBL1111635)
EC50
570±n/a nM
Citation
 Eliahu, S; Martín-Gil, A; Perez de Lara, MJ; Pintor, J; Camden, J; Weisman, GA; Lecka, J; Sévigny, J; Fischer, B 2-MeS-beta,gamma-CCl2-ATP is a potent agent for reducing intraocular pressure. J Med Chem 53:3305-19 (2010) [PubMed]  Article 
Target
Name:
P2Y purinoceptor 1
Synonyms:
P2RY1 | P2RY1_MELGA
Type:
n/a
Mol. Mass.:
41199.64
Organism:
Meleagris gallopavo
Description:
n/a
Residue:
362
Sequence:
MTEALISAALNGTQPELLAGGWAAGNASTKCSLTKTGFQFYYLPTVYILVFITGFLGNSVAIWMFVFHMRPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDVMCKLQRFIFHVNLYGSILFLTCISVHRYTGVVHPLKSLGRLKKKNAVYVSSLVWALVVAVIAPILFYSGTGVRRNKTITCYDTTADEYLRSYFVYSMCTTVFMFCIPFIVILGCYGLIVKALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYLPFHVMKTLNLRARLDFQTPQMCAFNDKVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKSSRRSEPNVQSKSEEMTLNILTEYKQNGDTSL
  
Inhibitor
Name:
BDBM50315825
Synonyms:
({[({[(2R,3S,4R,5R)-5-[6-amino-2-(methylsulfanyl)-9H-purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methoxy}(boranuidyl)phosphoryl)oxy]phosphinato}dichloromethyl)phosphonate | CHEMBL2448446
Type:
Small organic molecule
Emp. Form.:
C12H19BCl2N5O11P3S
Mol. Mass.:
616.009
SMILES:
BP(=O)(OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)nc(SC)nc12)OP(O)(=O)C(Cl)(Cl)P(O)(O)=O |r|
Structure:
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