Reaction Details Report a problem with these data
Target
Glutamate receptor 3
Ligand
BDBM50316375
Substrate
n/a
Meas. Tech.
ChEMBL_628117 (CHEMBL1108128)
EC50
1660±n/a nM
Citation
 Fleming, JJ; England, PM Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands. Bioorg Med Chem 18:1381-7 (2010) [PubMed]  Article 
Target
Name:
Glutamate receptor 3
Synonyms:
AMPA-selective glutamate receptor 3 | GLUR3 | GLURC | GRIA3 | GRIA3_HUMAN | GluR-3 | GluR-C | GluR-K3 | Glutamate receptor 3 | Glutamate receptor ionotropic AMPA | Glutamate receptor ionotropic, AMPA 3
Type:
PROTEIN
Mol. Mass.:
101172.14
Organism:
Homo sapiens (Human)
Description:
ChEMBL_468627
Residue:
894
Sequence:
MARQKKMGQSVLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFPTDADVQFVIQMRPALKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSASSENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCYKSRAESKRMKLTKNTQNFKPAPATNTQNYATYREGYNVYGTESVKI
  
Inhibitor
Name:
BDBM50316375
Synonyms:
CHEMBL1097939 | LY-404187 | N-[2-(4'-cyanobiphenyl-4-yl)propyl]propane-2-sulfonamide
Type:
Small organic molecule
Emp. Form.:
C19H28N2O2S
Mol. Mass.:
348.503
SMILES:
CC(C)S(=O)(=O)NCC(C)C1CCC(CC1)c1ccc(cc1)C#N |(35.08,-18.3,;35.1,-19.84,;36.44,-20.59,;33.78,-20.62,;32.99,-21.94,;34.53,-21.94,;32.44,-19.86,;31.11,-20.63,;29.77,-19.86,;29.77,-18.32,;28.44,-20.63,;28.44,-22.17,;27.12,-22.94,;25.78,-22.17,;25.77,-20.64,;27.1,-19.86,;24.45,-22.95,;23.11,-22.18,;21.79,-22.95,;21.79,-24.5,;23.12,-25.27,;24.46,-24.5,;20.45,-25.27,;19.11,-26.03,)|
Structure:
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