Reaction Details Report a problem with these data
Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50317115
Substrate
n/a
Meas. Tech.
ChEMBL_630653 (CHEMBL1111087)
EC50
1086±n/a nM
Citation
 Ye, XY; Chen, S; Zhang, H; Locke, KT; O'Malley, K; Zhang, L; Srivastava, R; Miao, B; Meyers, D; Monshizadegan, H; Search, D; Grimm, D; Zhang, R; Lippy, J; Twamley, C; Muckelbauer, JK; Chang, C; An, Y; Hosagrahara, V; Zhang, L; Yang, TJ; Mukherjee, R; Cheng, PT; Tino, JA Synthesis and structure-activity relationships of 2-aryl-4-oxazolylmethoxy benzylglycines and 2-aryl-4-thiazolylmethoxy benzylglycines as novel, potent PPARalpha selective activators- PPARalpha and PPARgamma selectivity modulation. Bioorg Med Chem Lett 20:2933-7 (2010) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha)
Type:
Enzyme
Mol. Mass.:
52222.08
Organism:
Homo sapiens (Human)
Description:
Q07869
Residue:
468
Sequence:
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
  
Inhibitor
Name:
BDBM50317115
Synonyms:
2-((3-((2-(2,4-difluorophenyl)oxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid | CHEMBL1087336
Type:
Small organic molecule
Emp. Form.:
C21H18F2N2O6
Mol. Mass.:
432.3742
SMILES:
COC(=O)N(CC(O)=O)Cc1cccc(OCc2coc(n2)-c2ccc(F)cc2F)c1
Structure:
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