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Target
Apoptosis regulator Bcl-2
Ligand
BDBM50318190
Substrate
n/a
Meas. Tech.
ChEMBL_628976 (CHEMBL1120826)
IC50
3200±n/a nM
Citation
 Feng, Y; Ding, X; Chen, T; Chen, L; Liu, F; Jia, X; Luo, X; Shen, X; Chen, K; Jiang, H; Wang, H; Liu, H; Liu, D Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors. J Med Chem 53:3465-79 (2010) [PubMed]  Article 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM50318190
Synonyms:
(Z)-3-((2-Methoxy-4-((7-(4-methoxyphenyl)-9-oxo-5H-benzo[h]-thiazolo[2,3-b]quinazolin-10(6H,7H,9H)-ylidene)methyl)phenoxy)-methyl)benzoic Acid | CHEMBL1098324
Type:
Small organic molecule
Emp. Form.:
C37H30N2O6S
Mol. Mass.:
630.709
SMILES:
COc1ccc(cc1)C1C2=C(N=c3s\c(=C/c4ccc(OCc5cccc(c5)C(O)=O)c(OC)c4)c(=O)n13)c1ccccc1CC2 |c:10,t:12|
Structure:
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