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Target
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
Ligand
BDBM50318193
Substrate
n/a
Meas. Tech.
ChEMBL_628975 (CHEMBL1120825)
IC50
34400±n/a nM
Citation
 Feng, Y; Ding, X; Chen, T; Chen, L; Liu, F; Jia, X; Luo, X; Shen, X; Chen, K; Jiang, H; Wang, H; Liu, H; Liu, D Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors. J Med Chem 53:3465-79 (2010) [PubMed]  Article 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
Synonyms:
Bcl-2-related protein EAT/mcl1 | MCL1_MOUSE | Mcl-1 | Mcl1
Type:
Developmental protein
Mol. Mass.:
35215.08
Organism:
Mus musculus (Mouse)
Description:
n/a
Residue:
331
Sequence:
MFGLRRNAVIGLNLYCGGASLGAGGGSPAGARLVAEEAKARREGGGEAALLPGARVVARPPPVGAEDPDVTASAERRLHKSPGLLAVPPEEMAASAAAAIVSPEEELDGCEPEAIGKRPAVLPLLERVSEAAKSSGADGSLPSTPPPPEEEEDDLYRQSLEIISRYLREQATGSKDSKPLGEAGAAGRRALETLRRVGDGVQRNHETAFQGMLRKLDIKNEGDVKSFSRVMVHVFKDGVTNWGRIVTLISFGAFVAKHLKSVNQESFIEPLAETITDVLVRTKRDWLVKQRGWDGFVEFFHVQDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM50318193
Synonyms:
(Z)-3-(4-((7-(3-Methoxyphenyl)-9-oxo-5H-benzo[h]thiazolo[2,3-b]-quinazolin-10(6H,7H,9H)-ylidene)methyl)furan-2-yl)-4-methylbenzoicAcid | CHEMBL1095310
Type:
Small organic molecule
Emp. Form.:
C33H24N2O5S
Mol. Mass.:
560.619
SMILES:
COc1cccc(c1)C1C2=C(N=c3s\c(=C/c4ccc(o4)-c4cccc(c4)C(O)=O)c(=O)n13)c1ccccc1CC2 |c:10,t:12|
Structure:
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