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Target
Bcl-2-like protein 1
Ligand
BDBM50318209
Substrate
n/a
Meas. Tech.
ChEMBL_628973 (CHEMBL1120823)
IC50
72000±n/a nM
Citation
 Feng, Y; Ding, X; Chen, T; Chen, L; Liu, F; Jia, X; Luo, X; Shen, X; Chen, K; Jiang, H; Wang, H; Liu, H; Liu, D Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors. J Med Chem 53:3465-79 (2010) [PubMed]  Article 
Target
Name:
Bcl-2-like protein 1
Synonyms:
Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:
Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:
26039.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM50318209
Synonyms:
(Z)-2-(3-((5-(2-Methoxyphenyl)-3-oxo-7-phenyl-3,5-dihydro-2Hthiazolo[3,2-a]pyrimidin-2-ylidene)methyl)phenoxy)acetic Acid | CHEMBL1094444
Type:
Small organic molecule
Emp. Form.:
C28H22N2O5S
Mol. Mass.:
498.55
SMILES:
COc1ccccc1C1C=C(N=c2s\c(=C/c3cccc(OCC(O)=O)c3)c(=O)n12)c1ccccc1 |c:10,t:12|
Structure:
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