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Target
Solute carrier family 22 member 8
Ligand
BDBM50133599
Substrate
n/a
Meas. Tech.
ChEMBL_646885 (CHEMBL1217026)
IC50
6600±n/a nM
Citation
 Mattes, H; Carcache, D; Kalkman, HO; Koller, M alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) antagonists: from bench to bedside. J Med Chem 53:5367-82 (2010) [PubMed]  Article 
Target
Name:
Solute carrier family 22 member 8
Synonyms:
OAT3 | Organic anion transporter 3 | S22A8_HUMAN | SLC22A8 | hOAT3
Type:
PROTEIN
Mol. Mass.:
59870.13
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1486920
Residue:
542
Sequence:
MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTGPWVLPMGPNGKPERCLRFVHPPNASLPNDTQRAMEPCLDGWVYNSTKDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQEPEVEKASQRIPLQPHGPGLGSS
  
Inhibitor
Name:
BDBM50133599
Synonyms:
(7-Imidazol-1-yl-6-nitro-2,3-dioxo-3,4-dihydro-2H-quinoxalin-1-yl)-acetic acid | CHEMBL119625 | YM-872 | ZONAMPANEL
Type:
Small organic molecule
Emp. Form.:
C13H9N5O6
Mol. Mass.:
331.2405
SMILES:
OC(=O)Cn1c2cc(c(cc2[nH]c(=O)c1=O)[N+]([O-])=O)-n1ccnc1
Structure:
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